© - UVic Genome BC Proteomics Centre

Results for FDA Assay|UVic MRMAssayDB

You searched for: FDA Assay


The proteomics community possesses a large and increasing amount of knowledge on precise and reproducible targeted assays, but these assays are not yet utilized to their full potential, particularly for clinical applications. The US Food and Drug Administration (FDA) has listed 1140 approved clinical tests, 208 of which are associated with 253 proteins. Using MRMAssayDB, an integrative resource on targeted proteomics assays, we have data-mined all of the available MRM assays to determine which ones can be used for these FDA-approved markers. Because MRMAssayDB links all assays to DrugBank and other knowledge bases, and to protein-protein interactions, it enables straight-forward design of multiplexed MRM assays for studying the pathways and interactions that involve these FDA-approved protein biomarkers.


UniProtKB Accession Protein Gene Organism Subcellular localization Stripped Peptide Sequence Modified Peptide Sequence Peptide unique in proteome Peptide present in isoforms PeptideTracker ID PeptideTracker Transitions PASSEL ID PASSEL Transitions SRMAtlas ID SRMAtlas Transitions CPTAC ID CPTAC Transitions PanoramaWeb ID PanoramaWeb Transitions Peptide assay in resources Best Transitions Pathway Protein–protein interaction (PPI) Involvement in disease 3D structure Go Term Name Drug Bank Assays for FDA approved Marker Mean Concentration
UniProtKB Accession Protein Gene Organism Subcellular localization Stripped Peptide Sequence Modified Peptide Sequence Peptide unique in proteome Peptide present in isoforms PeptideTracker ID PeptideTracker Transitions PASSEL ID PASSEL Transitions SRMAtlas ID SRMAtlas Transitions CPTAC ID CPTAC Transitions PanoramaWeb ID PanoramaWeb Transitions Peptide assay in resources Best Transitions Pathway Protein–protein interaction (PPI) Involvement in disease 3D structure Go Term Name Drug Bank Assays for FDA approved Marker Mean Concentration

Summary of results


The number of peptides entries in MRMAssayDB, sorted by organism
Species Name Number of unique entries
Homo sapiens 6182 peptide assay corresponding to 235 proteins
Total 6182 peptide assay corresponding to 235 proteins
Uniqueness and presence in isofroms
Database name Peptide uniqueness in proteome(%) Peptide is specific to one protein isoform(%)
PeptideTracker 93.39% 0.0%
PASSEL 94.51% 0.0%
SRMAtlas 88.06% 0.0%
CPTAC 95.45% 0.0%
PanoramaWeb 89.8% 0.0%
The number of peptides entries in MRMAssayDB, sorted by sub cellular location (Top50)
Sub cellular location Number of unique entries(Proteins)
Secreted 110
Cell membrane 48
Cytoplasm 43
Membrane 20
Endoplasmic reticulum membrane 19
Nucleus 16
Lysosome membrane 15
Golgi apparatus 14
Endosome membrane 11
Late endosome membrane 9
Lysosome 8
Cell projection 7
Cell junction 6
Mitochondrion 5
Endoplasmic reticulum 4
Cell surface 4
Chromosome 4
Cytoplasmic vesicle 3
Microsome membrane 3
Membrane raft 3
Mitochondrion inner membrane 3
Lysosome lumen 2
Perikaryon 2
Peroxisome 2
Melanosome 2
Apical cell membrane 2
Cytoplasmic granule 2
Mitochondrion matrix 2
Endosome 2
Mitochondrion membrane 1
Basolateral cell membrane 1
Cleavage furrow 1
Lipid droplet 1
Endomembrane system 1
Recycling endosome membrane 1
Nucleus matrix 1
Early endosome membrane 1
Mitochondrion outer membrane 1
Microsome 1
Recycling endosome 1
Lateral cell membrane 1
The number of peptides entries in MRMAssayDB, sorted by GO term name (Top50)
GO Term Name Number of unique entries(Proteins)
protein homodimerization activity 21
protease binding 12
nucleoplasm 14
blood microparticle 34
leukocyte migration 6
identical protein binding 42
Golgi lumen 12
intracellular membrane-bounded organelle 14
cell surface 42
proteolysis 22
acute-phase response 14
platelet degranulation 29
plasma membrane 97
serine-type endopeptidase activity 23
Golgi apparatus 28
blood coagulation, intrinsic pathway 14
extracellular region 117
external side of plasma membrane 20
endoplasmic reticulum 24
cytosol 58
endopeptidase inhibitor activity 10
regulation of complement activation 10
ATP binding 17
membrane 42
cell adhesion 15
spermatogenesis 6
endoplasmic reticulum lumen 29
metal ion binding 25
platelet alpha granule lumen 23
cellular protein metabolic process 31
extracellular matrix organization 11
extracellular space 108
integral component of plasma membrane 32
collagen-containing extracellular matrix 36
vesicle 6
heparin binding 12
neuronal cell body 10
nucleus 39
neutrophil degranulation 38
blood coagulation 29
extracellular exosome 120
receptor-mediated endocytosis 11
enzyme binding 16
protein-containing complex 12
signal transduction 20
Golgi membrane 28
cytoplasm 47
signaling receptor binding 31
post-translational protein modification 19
integral component of membrane 15

Kegg pathway coverage (Top 10)


Distribution of proteins and peptides among different databases.

      Unique Proteins



      Unique Peptides